scDRS_data_release_030122

Data files used for reproducing main results of the paper (revision 1).<br>- downstream_file.zip: scDRS gene-level correlation on the TMS FACS data for 74 diseases/traits.<br>- gold_standard_gs.zip: drug targets and Mendelian disease genes, consistent with Supp. Table<br>- score_file.zip: (1) scDRS score files for TMS FACS + hepatocyte signatures, (2) scDRS score files for Zeisel et al. 2015 (brain traits + inferred spatial coordinates).<br><br>- gene_annotation.zip: (1) MAGMA p-values for all genes and the 74 diseases/traits, (2) mouse-human homologs, (3) cell-cycle signatures in Macosko et al. 2015 Cell. <br><br>- gs_file.zip: (1) .gs file (with GWAS MAGMA z-score weights) for the 74 diseases/traits (magma_10kb_top1000_zscore.74_traits.rv1.gs), (2) batch .gs files for the 75 diseases/traits (magma_10kb_top1000_zscore.75_traits.batch) (including an additional file for PASS_BIP_Stahl2019 used in the initial submission)<br><br>- single_cell_data.zip: (1) reprocessed TMS FACS T cell data (./tms_proc/tcell.facs.annot.h5ad), (2) reprocessed TMS FACS hepatocytes data (./tms_proc/hep.facs_annot.h5ad), (3) Zeisel et al. 2015 processed data ./zeisel_2015<br>- sumstats.zip: GWAS summary statistics of the 74 diseases/traits<br>- tabula_muris_senis.zip: TMS FACS scRNA-seq data<br>- supp_table.zip: (1) disease information (trait_info.tsv), consistent with Supp. Table. (2) all supp. tables (supp_tables.xlsx), same as Supp. Table in the paper.