Anti-HBc IgM associates with acute flare and HBeAg/HBsAg loss in chronic hepatitis B patients with acute exacerbation

A total of 419 chronic hepatitis B (CHB) patients with acute exacerbation (AE) in Chongqing, China were included in this study to investigate the values of hepatitis B core antibody (anti-HBc) IgM in CHB-AE. The prevalence, clinical characteristics of anti-HBc IgM, and its relationship with the outcomes of CHB were assessed.

本研究纳入中国重庆地区共计419例慢性乙型肝炎（chronic hepatitis B, CHB）急性加重（acute exacerbation, AE）患者，旨在探讨乙型肝炎核心抗体（hepatitis B core antibody, anti-HBc）IgM在CHB-AE中的临床价值，并对anti-HBc IgM的阳性检出率、临床特征及其与CHB预后结局的相关性进行了评估。