Maladaptive Positive Feedback Production of ChREBPβ Drives Glucotoxic β-Cell Failure

Conclusions: ChREBPbeta is necessary for adaptive beta cell expansion, but drives glucose toxicity when overexpressed, mimicking the graded effect of Myc overexpression in beta cells.结论：碳水化合物反应元件结合蛋白β（ChREBPbeta）是适应性胰岛β细胞增殖所必需的，但当其过表达时会诱发葡萄糖毒性，其效应与胰岛β细胞中Myc过表达所产生的梯度效应一致。