Structural Biology at EMBL Grenoble, IBS-CIBB and IAB

The proposals covers a broad range of structural biology projects related to pathogen biology, host-pathogen interactions, RNA biology and structure-based drug development that are carried out by PIs at EMBL Grenoble, IBS-CIBB and IAB. The proposers have long-standing experience in the use, as well as the development of beam lines for macromolecular crystallography and have participated in successive BAG applications over the years, mostly at the ESRF but also at other synchrotrons (e.g. Soleil, Petra III, Diamond, SLS).

本提案涵盖了由欧洲分子生物学实验室格勒诺布尔分部（EMBL Grenoble）、IBS-CIBB及IAB的主要研究者（Principal Investigators，PIs）主持开展的多类结构生物学研究项目，研究范畴覆盖病原生物学、宿主-病原互作、RNA生物学以及基于结构的药物开发方向。提案方在大分子晶体学光束线的使用与开发领域拥有长期积淀的丰富经验，且多年来多次参与BAG（光束线分配工作组）相关申请，主要依托欧洲同步辐射光源（European Synchrotron Radiation Facility，ESRF）开展实验，同时也使用了其他同步辐射光源，包括SOLEIL、PETRA III、Diamond及SLS。