Assessment of Drug Flow Rate in Skin Cancer Therapy for Enhancing the Drug Delivery System

Abstract The major impact in the clinical field is the harm posed by cancer. One most common type of cancer occurs in the skin. Though the conventionally existing modalities are successful in some cases, there is a need for new sensible methods to detect tumors at their initial stage. In accordance to these reasons and in addition to the incapability of the drugs to cross cellular barriers in skin the conventional administration methods are often compromised. To eradicate these problems the research work aims to develop the electrical analogue of skin involving layers like dermis, subcutaneous tissues, bones and muscular layers. The mathematical model has been developed to determine the electrical network of skin. The response of different skin layers are analyzed through simulation studies. It is observed that the cells present in each layer absorbs some amount of drug and let out the remaining to the neighboring layers. Further to minimize the diffusion rate of the drug a conventional controller has been incorporated and the results are analyzed by the contrast of the absorption and diffusion capacities for different layers of skin.

摘要：临床医学领域中，癌症是造成主要危害的疾病之一，皮肤癌为其中最为常见的癌症类型。尽管现有常规诊疗手段在部分病例中已取得一定成效，但仍亟需开发新型精准方法以实现肿瘤的早期检测。基于上述需求，加之药物无法穿透皮肤细胞屏障，常规给药方式的效果往往大打折扣。为解决上述问题，本研究旨在构建包含真皮（dermis）、皮下组织（subcutaneous tissues）、骨骼及肌肉层的皮肤电学等效模型（electrical analogue）。本研究已开发用于解析皮肤电学网络的数学模型，并通过仿真研究对不同皮肤层的电学响应特性进行了分析。研究观察到，各层皮肤细胞会吸收部分药物，并将剩余药物释放至相邻皮肤层。为进一步降低药物扩散速率，本研究引入了常规控制器，并通过对比不同皮肤层的药物吸收与扩散能力对结果进行了分析。