Transport of RCbl within the body

The steps of transport of cobalamins (RCbl) from the enterocyte to the cells in which it will function as a cofactor, together with its reuptake in the renal tubule, are annotated here. While methylcobalamin is the predominant cobalamin in the blood (Chu et al. 1993), other cobalamins including cyanocobalamin and adenosylcobalamin are also present and the proteins involved in these processes accommodate all of them (Banerjee et al. 2021; Nielsen et al. 2012; Quadros 2010). This broad specificity is indicated by annotating R-cob(III)alamin (RCbl - CHEBI:140785) as the cargo in all of these processes.

本数据集详细记载了钴胺素（RCbl）从肠上皮细胞向其将作为辅因子发挥功能的细胞转运的过程，以及其在肾小管中的再摄取情况。尽管甲基钴胺素（Chu et al. 1993）是血液中占主导地位的钴胺素，但氰钴胺素和腺苷钴胺素等其他钴胺素亦同时存在，且参与这些过程的蛋白质能够适应所有这些钴胺素（Banerjee et al. 2021; Nielsen et al. 2012; Quadros 2010）。这种广泛的特异性通过标注R-钴(III)胺素（RCbl - CHEBI:140785）为所有这些过程中的载运物而得以体现。