The Effectiveness of Prone Positioning in Improving Oxygenation and Clinical Outcomes in Patients with Acute Respiratory Distress Syndrome (ARDS): A Quantitative Study

Background: Prone positioning is a therapeutic intervention used in patients with Acute Respiratory Distress Syndrome (ARDS) to improve oxygenation and clinical outcomes. This study aimed to evaluate the effectiveness of prone positioning in improving oxygenation and clinical outcomes in ARDS patients. Methods: A prospective observational study was conducted in the ICU of specialized military hospital . Fifty patients with moderate to severe ARDS were included. Prone positioning was performed according to a standardized protocol. Outcome measures included changes in PaO2/FiO2 ratio, ICU mortality, ventilator-free days, and ICU length of stay. Results: Prone positioning led to a significant improvement in oxygenation, with an increase in the PaO2/FiO2 ratio from baseline to after 16 hours of prone positioning (p &lt; 0.001). Clinical outcomes included an ICU mortality rate of 28%, a median ICU length of stay of 12 days, and a median ventilator-free days of 12 at day 28. Conclusion: Prone positioning effectively improved oxygenation and was associated with favorable clinical outcomes in ARDS patients. These findings support the use of prone positioning as part of the management strategy for ARDS.背景：俯卧位通气是急性呼吸窘迫综合征（Acute Respiratory Distress Syndrome，ARDS）患者的临床治疗干预措施，用于改善氧合状态与临床转归。本研究旨在评估俯卧位通气对ARDS患者氧合及临床结局的改善效果。 方法：本研究为前瞻性观察性研究，在某专科军队医院重症监护室（Intensive Care Unit，ICU）开展。共纳入50例中重度ARDS患者，按照标准化操作方案实施俯卧位通气。本次研究的结局指标包括动脉血氧分压/吸入氧浓度比（PaO2/FiO2）的变化、ICU病死率、无呼吸机使用天数以及ICU住院时长。 结果：俯卧位通气可显著改善患者氧合状态，俯卧位通气实施16小时后，PaO2/FiO2比值较基线水平显著升高（p < 0.001）。临床结局指标显示，患者ICU病死率为28%，ICU中位住院时长为12天，第28天时的中位无呼吸机使用天数为12天。 结论：俯卧位通气可有效改善ARDS患者的氧合状态，并与良好的临床结局显著相关。本研究结果支持将俯卧位通气纳入ARDS患者的临床管理策略。