Sirt6 deficiency-induced senescent NK cell populations are associated with resistance to anti-PD-1 therapy.

In this study, we summarize senescence results in remodeling NK cell immunity and is associated with ICB resistance and poor clinical outcomes in cancer. We also survey insights into mechanisms of NK cell dysfunction in senescence and discuss the impacts of senescence on the efficacy of cancer immunotherapy. These results suggest that senescence has an important role in the dysfunction phenotype of tumor-infiltrated NK cells. Eliminating senescence NK cells may be a promising strategy for immune checkpoint blockage.