Differentially regulated genes in wildtype compared to Per2−/− mice during myocardial ischemia and reperfusion.

Shown are the number of genes that were differentially regulated in wildtype or Per2−/− mice using different ischemia and reperfusion protocols: wildtype or Per2−/− mice were exposed to 1.) Ischemia of 30 minutes without reperfusion (I30), 2.) Ischemic preconditioning (consisting of 4 times 5 minutes of ischemia and 5 minutes of reperfusion, IP0), and 3.) 30 minutes of ischemia followed by 60 minutes of reperfusion (I30R60).