Lewis Acid Catalyzed Highly Stereoselective Domino-Ring-Opening Cyclization of Activated Aziridines with Enolates: Synthesis of Functionalized Chiral γ-Lactams
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https://figshare.com/articles/dataset/Lewis_Acid_Catalyzed_Highly_Stereoselective_Domino_Ring_Opening_Cyclization_of_Activated_Aziridines_with_Enolates_Synthesis_of_Functionalized_Chiral_Lactams/2728786
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资源简介：
A highly enantio- and diastereoselective Lewis acid catalyzed SN2-type ring opening followed by cyclization of aziridines with active methylene carbon nucleophiles to functionalized chiral γ-lactams in a domino fashion has been developed. γ-Lactams have been desulfonated and decarboxylated, providing pyrrolidone-3-carboxylate and N-tosylpyrrolidinone derivatives, respectively, in good yields.
创建时间：
2016-02-24
