Potent Lung Tumor Promotion by Inhaled MWCNT
收藏ICPSR2025-01-01 更新2026-04-16 收录
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https://www.datalumos.org/datalumos/project/239445/version/V1/view
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资源简介：
In the lung, carcinogenesis is a multi-stage process that includes initiation by a genotoxic agent, promotion that expands the population of cells with damaged DNA to form a tumor, and progression from benign to malignant neoplasms. We have previously shown that Mitsui-7, a long and rigid multi-walled carbon nanotube (MWCNT), promotes pulmonary carcinogenesis in a mouse model. To investigate the potential exposure threshold and dose-response for tumor promotion by this MWCNT, 3-methylcholanthrene (MC) initiated (10 μg/g, i.p., once) or vehicle (corn oil) treated B6C3F1 mice were exposed by inhalation to filtered air or MWCNT (5 mg/m3) for 5 hours/day for 0, 2, 5, or 10 days and were followed for 17 months post-exposure for evidence of lung tumors.
提供机构：
United States Department of Health and Human Services. Centers for Disease Control and Prevention. National Institute of Occupational Safety and Health
创建时间：
2025-01-01
