Bone marrow aspirate smear of a VEXAS syndrome patient

This dataset contains the digital slides of the bone marrow aspirate smears of a VEXAS syndrome patient from year 0, year 5, and year 7. 

VEXAS syndrome is an autoinflammatory syndrome caused by somatic mutations in UBA1, a gene coding for the ubiquitin-activating enzyme. The disease was first defined in 2020 by Beck et al[1]. The patients develop refractory systemic inflammation, which can manifest as relapsing polychondritis among others. They also develop haematological symptoms, most frequently macrocytic anaemia, and the presence of vacuoles in the affected cells in the bone marrow is a key feature. 

In the article[2] linked to this dataset, we provided the table (Supplementary Table S1) of the change in the numbers and the percentages of the vacuole-positive cells by maturation stage and by lineage in the bone marrow from three bone marrow aspirate examination over seven years. We scanned the smear slides to share with the scientific community. 

[1]Beck DB, Ferrada MA, Si...

本数据集包含一名VEXAS综合征（VEXAS syndrome）患者在第0年、第5年及第7年的骨髓抽吸涂片数字化切片。

VEXAS综合征是一类由UBA1基因（UBA1）体细胞突变引发的自身炎症综合征，UBA1基因编码泛素激活酶。该病于2020年由Beck等人首次明确界定[1]。患者会出现难治性全身炎症，临床表现可涵盖复发性多软骨炎等多种病症；同时还会伴发血液学症状，其中以大细胞性贫血最为常见，骨髓受累细胞内出现空泡是该病的核心特征之一。

在本数据集关联的学术论文[2]中，我们提供了补充附表S1（Supplementary Table S1），该表格统计了七年间三次骨髓抽吸检查中，骨髓内按成熟阶段与细胞谱系划分的空泡阳性细胞数量及占比变化。我们对涂片玻片进行数字化扫描，以供科研共同体共享使用。

[1]Beck DB, Ferrada MA, Si...