Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity

Protein Data Bank Japan2024-02-28 更新2026-03-21 收录

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Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity Descriptor: (4R,6S,8S,12R,14R,16Z,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9,11-dioxodocos-16-enoic acid, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma Authors: Wang, R, Li, Y. Deposit date: 2012-06-05 Release date: 2013-03-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes. Diabetologia, 56, 2013

创建时间：

2012-06-05