Summary of leading SNPs from the 19 loci showing strong or suggestive association with IA in a multinational GWAS containing Finnish patients [12].

Association results with intracranial aneurysm (IA) by Yasuno and colleagues are followed by our meta-analysis association results with systolic blood pressure (SBP), with the ROBUST and the ADVANCED models, respectively.
Table first shows association p-values with IA for the Finnish sub-group from the multinational GWAS (IA GWAS), followed by results from our meta-analysis of association with systolic blood pressure (SBP) with the ROBUST and ADVANCED models. In the ROBUST model of association we corrected for gender and age and in the ADVANCED model we further corrected for BMI, smoking habits and alcohol consumption.
Genomic positions are based on the human genome build 36. Alleles are reported on the forward strand of the reference genome. The effects are reported for the alleles increasing risk for IA in the Yasuno et al. studies [12], [13]. If SNP is intergenic, Gene represents the nearest gene. SNPs are directly genotyped unless otherwise marked (* HM2 imputed SNP, ** 1000G+HM3 imputed SNP). Yasuno et al (2011) at 8q24.23 followed-up with rs1554349 instead of the lead SNP, rs6577930.
In bold: locus showing strongest association with SBP in meta-analysis.
#‘IA GWAS’ triplet column shows the Finnish sub-group (nFINN-IA-CASES = 912, nFINN-CONTROLS = 8180) association results on IA of the GWAS by Yasuno and colleagues, except for the PPA results, which is not Finnish sub-group specific, but counted for the whole multinational cohort.
##PPA: posterior probability of association with IA as calculated by Yasuno and colleagues for the multinational IA GWAS.
$‘SBP meta-analysis with ROBUST model’ and ‘with ADVANCED model’ twin-columns show results of our candidate locus meta-analysis with SBP as the outcome variable. SBP meta-analysis beta values are given for IA risk alleles.
OR: odds ratio, CI: confidence interval, SE: standard error.