TOP2A

ENCODES a protein that exhibits ATP binding (ortholog); chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN cerebellar granule cell differentiation (ortholog); cerebellar Purkinje cell differentiation (ortholog); chromosome condensation (ortholog); PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); adenoid cystic carcinoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex (ortholog); nucleolus (ortholog); nucleus (ortholog)

编码一种表现出ATP结合（同源）；染色质结合（同源）；DNA结合（同源）的蛋白质；涉及（同源）在小脑颗粒细胞分化；小脑浦肯野细胞分化；染色体凝缩；参与多柔比星药理学途径；依托泊苷药理学途径；依托泊苷药代动力学途径；与急性早幼粒细胞白血病（同源）；腺样囊性癌（同源）；肾上腺皮质癌（同源）相关；存在于DNA拓扑异构酶II（双链切割，ATP水解）复合物（同源）；核仁（同源）；细胞核（同源）