Chronic Gene Expression after Traumatic Brain Injury

This project continues our acute TBI studies and initiates chronic studies -- characterizing the temporal genomic profile of the injured brain up to 12 months post-TBI. Thus, the primary objective of this proposal is to determine the long-term effects of traumatic brain injury on gene expression in the hippocampus and cortex, two brain regions known to be particularly vulnerable to TBI.本项目延续了此前针对急性创伤性脑损伤（Traumatic Brain Injury，TBI）的研究，并启动慢性研究——对创伤后脑组织在创伤后长达12个月的时序基因组特征进行表征。因此本提案的核心目标为探明创伤性脑损伤对海马体与大脑皮层这两个已知对TBI尤其易感的脑区内基因表达的长期影响。