Supporting data for "Galactic Circos: User friendly Circos Plots within the Galaxy platform"

Circos is a popular software package for the circular visualization of complex datasets. Circos is a highly flexible tool. While especially popular in the field of genomic analysis, Circos enables interactive graphing of any analytical data, including alternative scientific domain data and non-scientific data. This high degree of flexibility also comes with a high degree of complexity, which may present an obstacle for researchers not trained in programming or the UNIX command line. The Galaxy platform provides a user-friendly graphical interface incorporating a broad range of "wrapped" command-line tools to facilitate accessibility. We have developed a Galaxy wrapper for Circos, thus combining the power of Circos with the accessibility and ease-of-use of the Galaxy platform. The combination significantly simplifies the specification and configuration of Circos plots for end-users while retaining the power to produce publication-quality visualizations of complex multidimensional datasets. Galactic Circos enables the creation of publication-ready Circos plots within the Galaxy platform. Users may download the full set of Circos configuration files of their plots for further manual development. This version of Circos is available as an open-source installable application from the Galaxy ToolShed, with its usage clarified in a training manual hosted by the Galaxy Training Network.

Circos是一款广受欢迎的软件包，用于复杂数据集的环形可视化。Circos是一款高灵活性工具。尽管其在基因组分析领域尤为普及，但Circos支持对任意分析数据进行交互式绘图，涵盖其他科学领域数据与非科学领域数据。不过这种高度灵活性也伴随着极高的操作复杂度，对于未接受过编程或UNIX命令行培训的研究人员而言，可能构成使用障碍。Galaxy平台提供了用户友好的图形界面，集成了大量封装式命令行工具以提升易用性。我们针对Circos开发了一款Galaxy封装器，从而将Circos的强大功能与Galaxy平台的易用性有机结合。该组合极大简化了终端用户对Circos绘图的参数设定与配置流程，同时保留了生成复杂多维数据集的可发表级可视化成果的能力。Galactic Circos可在Galaxy平台内生成符合发表标准的Circos绘图作品。用户可下载其绘图所用的全套Circos配置文件，以便进行后续的手动开发调整。该版本的Circos可通过Galaxy ToolShed获取为一款开源可安装应用，其使用方法已在Galaxy Training Network托管的培训手册中得到详细说明。