IBS BAG

The IBS BAG includes in this proposal IBS teams and external groups from CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2498 proposal and can be grouped into different topics as follows: host-pathogen interaction, new therapy targets, fundamental cellular mechanisms, membrane proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, cryo-EM, SAXS and NMR), together with other biophysical and biochemical studies, and very recently the use of AI, with the aim to fully understand the complexity of the biological macromolecular systems under study.

本提案中的IBS BAG涵盖IBS团队以及来自CEA-Cadarache（圣波尔勒迪朗斯）和IRBA（奥尔日河畔布雷蒂尼）的外部研究团队。本团队聚焦蛋白质的结构-功能关系研究，重点关注人类健康、生物技术及研究方法学领域。本项目绝大多数为MX-2498提案的延续性研究，可归纳为以下六大研究主题：宿主-病原体互作、新型治疗靶点、基础细胞机制、膜蛋白、生物技术应用以及研究方法学。部分项目采用整合研究策略，包括X射线晶体学（X-ray crystallography）、冷冻电子显微镜（cryo-EM）、小角X射线散射（SAXS）与核磁共振波谱（NMR），结合其他生物物理与生物化学研究手段，且近期引入了人工智能（AI）技术，旨在全面解析所研究的生物大分子系统的复杂性。