COG categories of genes in the L. interrogans genomes.

From the files generated by eggNOG-mapper v2, the columns corresponding to "gene name" and "COG categories" for each L. interrogans genome were copied into a new Excel file named "All_genomes_COG_analysis.xlsx". The information for each genome is contained in separate sheets, named after the corresponding genome. The comparative analysis was focused on finding differences in categories related to metabolic pathways, since most of them showed highly significant differences among the different groups (CG272 vs Others): [G] Carbohydrate transport and metabolism, [E] Amino acid transport and metabolism, [F] Nucleotide transport and metabolism, [H] Coenzyme transport and metabolism, [I] Lipid transport and metabolism, [P] Inorganic ion transport and metabolism. Therefore, genes related to these pathways were filtered, and then the list of genes for each genome was compared using the online tool https://www.molbiotools.com/listcompare.html. (XLSX)