Additional file 8: of Exome scale map of genetic alterations promoting metastasis in colorectal cancer

Table S7. EMV Cancer driver mutations according to CHASM algorithm. Chrom – chromosome number, Position – mutation position, Ref – reference base, Alt – variant base, Sample.ID – sample with mutation, HUGO.symbol – HUGO gene symbol, Protein.sequence.change – amino-acid change. CHASM.p.value – p-value for CHASM, dbSNP – identifier in dbSNP, 1000.Genomes/ ESP6500/ ExAC – allele frequencies in different exome-sequencing projects, COSMIC.ID – COSMIC identifier, Occurrences.in.COSMIC.by .primary.sites – organs, harboring somatic mutations in this gene in COSMIC database, ClinVar.Clinical.Significance – ClinVar clinical significance, Number.of.samples – number of samples with mutation, Qvalue – CHASM.p.value corrected for multiple testing with FDR method (XLSX 291 kb)

表S7 基于CHASM算法（CHASM）的EMV癌症驱动基因突变表。各字段含义如下：Chrom（染色体编号）、Position（突变位点）、Ref（参考碱基）、Alt（变异碱基）、Sample.ID（携带突变的样本标识符）、HUGO.symbol（HUGO基因符号）、Protein.sequence.change（氨基酸序列改变）、CHASM.p.value（CHASM检验的p值）、dbSNP（dbSNP数据库标识符）、1000.Genomes/ ESP6500/ ExAC（不同外显子组测序项目中的等位基因频率）、COSMIC.ID（COSMIC数据库标识符）、Occurrences.in.COSMIC.by.primary.sites（COSMIC数据库中按原发病灶分类的该基因体细胞突变受累器官）、ClinVar.Clinical.Significance（ClinVar临床意义注释）、Number.of.samples（携带该突变的样本数）、Qvalue（经错误发现率（FDR）法进行多重检验校正后的CHASM检验校正p值）（XLSX 291 kb）