PMACS-64

<b>Project title</b>: PMACS-64<b>Grant Information:</b> AHA Grant 9TPA34910007, Regulatory role of pericardial macrophages in myocardial infarction<b>Project Description:</b>· Animal Model: Myocardial Infarction· Animal Age: 8-12 Weeks· Animal Sex: Male and Female· Animal Strain: C57B6/J Lys^CreGATA6^fl/fl or Lys^Cre WT-like· Number: 28 mice· Groups: 4 Male Lys^CreGATA6^fl/fl, 6 Female Lys^CreGATA6^fl/fl, 10 Male Lys^Cre, 8 Female Lys^Cre, all infarcted· Experimental Conditions: Mice were given MI via LAD ligation. Animals were sacrificed at day 2 post-infarction. Hearts were collected and analyzed via Flow Cytometry. Results from this experiment were concatenated with results from PMACS-56 for analysis<b>Code/Scripts: </b>N/A<b>Licenses: </b>N/A

<b>项目名称</b>: PMACS-64<b>资助信息:</b> 美国心脏协会（American Heart Association, AHA）资助项目编号9TPA34910007，主题为「心包巨噬细胞在心肌梗死（Myocardial Infarction, MI）中的调控作用」<b>项目描述:</b>· 动物模型：心肌梗死模型· 动物周龄：8~12周· 动物性别：雌雄兼具· 动物品系：C57B6/J Lys^CreGATA6^fl/fl 或 Lys^Cre野生型· 实验动物总数：28只小鼠· 实验分组：4只雄性Lys^CreGATA6^fl/fl、6只雌性Lys^CreGATA6^fl/fl、10只雄性Lys^Cre、8只雌性Lys^Cre，所有小鼠均已构建心肌梗死模型· 实验处理：通过左前降支（Left Anterior Descending, LAD）结扎术诱导小鼠心肌梗死，于梗死后第2天处死动物，采集心脏组织并通过流式细胞术（Flow Cytometry）进行分析· 数据分析：本实验所得结果将与PMACS-56的实验结果合并后开展分析<b>代码/脚本: </b>N/A<b>授权协议: </b>N/A