The expression profiles of lncRNAs in hippocampus from mice with prenatal glyphosate exposure

In this study, the lncRNAs expression pattern in hippocampus of postnatal day (PND) 28 mice offsprings which were exposured by glyphosate-based herbicide (GBH) during pregnancy and lactation was investigated. LncRNA microarray had detected 840 upregulated and 919 downregulated lncRNAs in the PND28 mice offsprings' hippocampus In this study, the isolated total RNA taken from two pooled samples of two groups, was used to acquire expression profiles, and the result shows 1759 differentially-expressed lncRNAs, some of them are known to be involved in brain development or the pathogenesis of neurodevelopmental disorders, indicate that dysregulated expression of lncRNAs may be involved in the mechanism of glyphosate-induced neurotoxicity.