TFF2 miRNA expression in Mus musculus

The aim of the study was to investigate whether the trefoil peptide genes, in concerted action with a miRNA regulatory network, were contributing to nutritional maintenance. Using a Tff2 knock-out mouse model, 48 specific miRNAs were noted to be significantly deregulated when compared to the wild type strain. n = 6 mus musculus wild type samples and n = 6 knock-down experiments have been screened for a currently known mus musculus miRNAs and validated by TaqMan本研究旨在探究三叶肽基因（trefoil peptide genes）与微小RNA（miRNA）调控网络协同作用时，是否参与营养维持过程。本研究采用Tff2敲除（Tff2 knock-out）小鼠模型，相较于野生型品系，共发现48种特异性微小RNA存在显著表达失调。本研究针对当前已知的小家鼠（mus musculus）微小RNA开展筛选，共纳入6份小家鼠野生型样本与6组敲低实验，并通过TaqMan法完成验证。