Gene expression changes of 4-hydroxy-m-phenylenediammonium dichloride-induced in renal cortex of rats

This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with 4-hydroxy-m-phenylenediammonium dichloride, and the gene expression profiles of renal cortex were analyzed using custom microarrays.本研究旨在基于致癌物染毒大鼠的基因表达谱，开发一种短期且高精度的肾脏致癌性预测方法。本研究以4-羟基间苯二胺二氯化物（4-hydroxy-m-phenylenediammonium dichloride）对雄性SD大鼠实施28天重复给药实验，并采用定制微阵列（custom microarrays）分析大鼠肾皮质的基因表达谱。