Cleaned dataset for PubChem AID 1159553: qHTS assay of retinoic acid receptor (RAR) agonists

This dataset is derived from PubChem BioAssay AID 1159553, titled "qHTS assay to identify small molecule agonists of the retinoic acid receptor (RAR) signaling pathway". The original assay is part of the Tox21 program and measures activation of retinoic acid receptor (RAR) signaling using a luciferase reporter gene assay under the control of retinoic acid response elements (RARE) in a cell-based system. Original dataset statistics: - Tested compounds: 7,331 - Active (agonists): 364 - Inactive: 5,952 Data preprocessing: - Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations. Final cleaned dataset: - Total compounds: 5,942 - Positive (agonists): 300 - Negative (inactive): 5,642