FAST ACTION ENROFLOXACIN ASSOCIATED WITH ORAL ELECTROLYTE AND ENERGY REPLACEMENT OR ENDOVENONOUS FLUID THERAPY IN THE TREATMENT OF NEONATAL BOVINE DIARRHEA

Abstract The objective of this study was to evaluate the use of fast action enrofloxacin and its association with oral or intravenous support by assessing the clinical response, serum metabolites and body development of the dairy calves with diarrhea. We used 56 animals divided in groups: Healthy Group (n=5), Antibiotic Group (ATB; n=15), Antibiotic + Intravenous Support Group (ATB+IS; n=9), Antibiotic + Oral Support Group (ATB+OS; n=16), Intravenous Support Group (IS; n=11). All animals were daily monitored during the first 42 days of life and, when diagnosed diarrhea, was conducted clinical evaluation and blood sampling at 0, 24, 72 and 120 h for hematologic evaluation and serum metabolites, and weekly to body development. All the groups receiving the antibiotic had improved consistency of feces. ATB+OS had positive results on the levels of lymphocytes, eosinophils and chlorides. ATB+IS showed higher values of total proteins and globulins. In relation to body development, there was no difference between groups. Thus, enrofloxacin fast action was effective in reversing diarrhea and its association with oral replacement solution helped the clinical response by improving leukocyte pattern and chlorides. Since its association with the intravenous fluid got a better response in protein metabolism.

摘要 本研究旨在评估速效恩诺沙星（enrofloxacin）的应用效果，及其联合口服或静脉支持疗法对腹泻奶牛犊牛的临床疗效、血清代谢物水平与生长发育的影响。本研究共纳入56头受试奶牛犊牛，分为5组：健康对照组（n=5）、抗生素组（ATB，n=15）、抗生素联合静脉支持组（ATB+IS，n=9）、抗生素联合口服支持组（ATB+OS，n=16）以及单纯静脉支持组（IS，n=11）。所有受试动物在出生后前42天每日接受监测；当确诊腹泻时，首先开展临床评估，并分别于0、24、72及120小时采集血样进行血液学与血清代谢物检测，同时每周监测其生长发育情况。结果显示，所有使用抗生素的受试组粪便性状均得到显著改善。抗生素联合口服支持组（ATB+OS）的淋巴细胞、嗜酸性粒细胞及氯化物水平呈现正向改善趋势；抗生素联合静脉支持组（ATB+IS）的总蛋白与球蛋白水平更高。在生长发育方面，各组间无显著差异。综上，速效恩诺沙星可有效逆转犊牛腹泻症状；其联合口服补液疗法可通过改善白细胞计数模式与氯化物水平优化临床响应，而联合静脉补液疗法则能在蛋白质代谢层面获得更优的改善效果。