DNA-hypermethylated human gastric cancer circumvents apoptosis in the absence of TP53 mutation.

This study was designed to identify genetic mutations specific for DNA methylation epigenotypes using exome targeted sequencing combined with genome-wide DNA methylation analysis on specimens from patients with gastric cancer. Comprehensive DNA methylation profile by Infinium 450k indicated that gastric cancer was clustered into four methylation epigenotypes (MEs): extremely high-ME (E-HME), high-ME (HME), low-ME (LME), and extremely low-ME (E-LME). Bisulphite converted DNA from the 35 gastric cancer cases were hybridised to the Infinium HumanMethylation450 BeadChip.