Significant enrichment of 45 MI/CAD-associated SNPs in specific cell types detected by enrichment analysis.

We examined whether 45 MI/CAD-associated loci were enriched in regions of inferred strong enhancer chromatin states [27] in specific cell types using NIH Roadmap data and two mammalian conservation algorithms, GERP and SiPhy-omega, implemented in HaploReg v2 [26]. We observed significant enrichment of MI/CAD-associated SNPs in specific cell types, including adipose nuclei, spleen and brain tissue. MI, myocardial infarction; CAD, coronary artery disease; SNP, single nucleotide polymorphism.