Borderline personality and substance use in women.

The association between borderline personality disorder (BPD) and substance use disorder (SUD) was examined in a predominantly psychiatric (77.6%) sample of 232 women. BPD proved to be a significant predictor of a lifetime diagnosis of SUD across four different categories: any SUD (including alcohol); alcohol use; drug use; and heroin, cocaine, or poly-substance use. BPD continued to be a predictor of SUD even when the effects of other cluster B and all cluster C PDs were controlled statistically. Antisocial personality disorder generally yielded larger odds ratios than BPD and emerged as a partial mediator of the relation between BPD and SUD. Histrionic PD was the only other PD that showed meaningful relations with SUD.

本研究纳入232名女性作为研究对象，其中77.6%为精神科就诊者，旨在探讨边缘型人格障碍（borderline personality disorder, BPD）与物质使用障碍（substance use disorder, SUD）之间的关联。研究结果显示，BPD可显著预测四类物质使用障碍的终生诊断结果，分别为任意类型物质使用障碍（含酒精使用障碍）、单纯酒精使用障碍、单纯药物使用障碍，以及海洛因、可卡因或多物质使用障碍。即便在控制了其他B群人格障碍与全部C群人格障碍的统计学效应后，BPD仍可作为SUD的独立预测因子。反社会型人格障碍的优势比（odds ratio）通常高于BPD，且在BPD与SUD的关联中发挥部分中介作用。表演型人格障碍是仅有的另一类与SUD存在统计学意义关联的人格障碍。