Prebiotics and butyric acid can replace colistin as a growth promoter for nursery piglets

ABSTRACT This study aimed to assess different prebiotic concentrations and principles, in addition to calcium butyrate, aiming to replace colistin as a growth promoter. The sample consisted of 120 piglets weaned at 22 days old with mean initial weight of 5.475 ± 0.719kg. The animals were assigned to random blocks in six treatments corresponding to the use of the following dietary additives: T1) colistin (40 ppm); T2) β-glucan/mannan-oligosaccharides (0.2%); T3) calcium butyrate (0.1%); T4) β-glucan/mannan-oligosaccharides (0.1%) + fructooligosaccharides (0.01%) + galactooligosaccharides (0.09%); T5) β-glucan/mannan-oligosaccharides (0.1%) + fructooligosaccharides (0.03%) + galactooligosaccharides (0.07%); and T6) β-glucan/mannan-oligosaccharides (0.1%) + fructooligosaccharides (0.05%) + galactooligosaccharides (0.05%). The results showed no difference among treatments for the performance parameters in any of the phases evaluated. For diarrhea incidence and intensity, the results indicated that the treatments with alternative additives had similar effects as the group treated with colistin. A significant difference was found for the profile of propionic acid (0.23% colistin and 0.32%, 0.36%, 0.37% additives) and total fatty acids (0.67% colistin and 0.97% additives) values in the caecum. The supplementation with different compositions and concentrations of prebiotics and butyric acid may viably replace colistin in controlling diarrhea and modulating volatile fatty acid production in the caecum.

摘要 本研究旨在评估不同浓度与种类的益生元（prebiotic），联合丁酸钙（calcium butyrate），以期替代黏菌素（colistin）作为仔猪生长促进剂。试验共纳入120头22日龄断奶仔猪，初始平均体重为5.475±0.719kg。试验动物采用随机区组设计，分为6个处理组，各组日粮添加以下添加剂：T1：黏菌素（40ppm）；T2：β-葡聚糖（β-glucan）/甘露寡聚糖（mannan-oligosaccharides，0.2%）；T3：丁酸钙（0.1%）；T4：β-葡聚糖/甘露寡聚糖（0.1%）+低聚果糖（fructooligosaccharides，0.01%）+低聚半乳糖（galactooligosaccharides，0.09%）；T5：β-葡聚糖/甘露寡聚糖（0.1%）+低聚果糖（0.03%）+低聚半乳糖（0.07%）；T6：β-葡聚糖/甘露寡聚糖（0.1%）+低聚果糖（0.05%）+低聚半乳糖（0.05%）。结果显示，各评估阶段的生长性能参数在各组间均无显著差异。就腹泻发生率与严重程度而言，各替代添加剂处理组与黏菌素处理组的防控效果相当。盲肠（caecum）内丙酸含量（黏菌素组为0.23%，各添加剂组分别为0.32%、0.36%、0.37%）与总脂肪酸含量（黏菌素组为0.67%，添加剂组为0.97%）存在显著差异。通过调整益生元与丁酸的组成及添加浓度，可切实可行地替代黏菌素，用于控制仔猪腹泻并调节盲肠内挥发性脂肪酸（volatile fatty acid）的生成。