Early-Onset Sepsis an NICHD/CDC Surveillance Study

This observational study was a surveillance of all infants born at NRN centers to identify all newborns who are diagnosed with early-onset sepsis (EOS) and/or meningitis. The purpose of the study was to establish current hospital-based rates of EOS among term and preterm infants in the era of intrapartum antibiotic prophylaxis; monitor the organisms associated with EOS and meningitis; compare asymptomatic and symptomatic infants by gestational age and pathogen; and monitor sepsis-associated mortality rates by pathogen group.

本项观察性研究针对NRN各中心的全部活产婴儿实施监测，以识别所有被确诊为早发性脓毒症（early-onset sepsis, EOS）和/或脑膜炎的新生儿。本研究的目标在于：确立产时抗生素预防（intrapartum antibiotic prophylaxis）时代下足月与早产婴儿的院内EOS当前发病率；监测与EOS及脑膜炎相关的病原菌；按胎龄与病原菌类型对比无症状与有症状婴儿；并按病原菌分组监测脓毒症相关死亡率。