FInnish National Protein Crystallography Consortium

The Finnish BAG encompasses 24 groups active in crystallography in Finland. The projects vary widely and include membrane proteins and protein complexes, other proteins involved in disease and antibiotics and drug development and discovery (ADP-ribosylation and several oncogenic proteins including kinases, biocatalysis, endoplasmic regulation and protein secretion) and several pathogen proteins and various enzyme targets and e.g. studies on phytochrome photoreceptors and complexes involved in actin dynamics regulation as well as membrane protein targets. Overall the BAG serves the national needs for highly variable projects, with different biological and biotechnological applications. Several project will benefit from microfocus beam lines and tunable wavelength options, others benefit from quick robust screening by MASSIF.

芬兰BAG（Finnish BAG）涵盖了芬兰境内24个活跃于晶体学领域的研究团队。其研究项目覆盖范围极广，包括膜蛋白与蛋白复合物、与疾病相关的其他蛋白、抗生素及药物开发与发现相关研究（涉及ADP-核糖基化过程、包括激酶在内的多种致癌蛋白、生物催化、内质网调控与蛋白分泌），还涵盖多种病原菌蛋白与各类酶靶点，例如植物色素光受体的相关研究、肌动蛋白动态调控相关复合物的分析，以及膜蛋白靶点研究。总体而言，该BAG可满足国内对高度多样化项目的需求，这些项目涉及不同的生物学与生物技术应用场景。部分项目将受益于微聚焦光束线与可调波长选项，其余项目则可通过MASSIF系统实现快速可靠的筛选。