Supplementary Tables S1-10 from Genetic and Epigenetic Characterization of Growth Hormone–Secreting Pituitary Tumors

Supplementary Tables S1-S10 shows: 1) All the coding region variants (missense, premature stop codon, frameshift) of 21 sequenced somatotropinomas that passed the somatic filtering. 2) Results of correlation tests between genetic instability (GI%) and clinical variables. 3) Differentially expressed transcripts (FDR {less than or equal to} 5%, FC -2 {greater than or equal to} x {greater than or equal to} 2) in CA- and CS-tumors. 4) Significantly enriched canonical pathways carried out from differentially expressed genes (FDR < 5% and |FC|>2; CA- vs CS-tumors). 5) Immunostaining intensities of total- and phosphorylated-RB1 in CA- and CS-tumors. 6) CpG quality statistics. 7) Replication timing and CpG methylation. 8) Differentially methylated regions (DMRs) between Gsp+ versus Gsp- tumors, and nearby genes. 9) Integration of DMRs with matched transcriptomes by expression quantitative trait methylation (eQTM) analysis (at 5% FDR). 10) The complete list of significantly (p< 0.05) enriched cis-eQTM pathways.