Uppsala Longitudinal Study of Adult Men (ULSAM): Age 77

ULSAM started as a health investigation, focused at identifying metabolic risk factors for cardiovascular disease, to which all 50 year-old men living in Uppsala in 1970 were invited. Of these, 82% (2322 men) participated in the investigation. The men were thereafter investigated again at ages 60, 70, 77, 82, 88 and 93 years. In the 93 years investigation, which was completed in spring 2015, even spouses to the men from original cohort have participated. ULSAM is focused on several areas with a wide range of phenotypes collected. These areas include glucose and insulin metabolism, blood pressure, anthropometry, lipids and fatty acid composition, diet, cognitive function, socio-economic factors, heredity, medical history, and common risk factors for cardiovascular disease. In the latest investigation we are particularly focusing on the factors leading to healthy ageing. The longitudinal design of the study contributes to the collection of the same (or similar) phenotypes at several points in time. The loss of follow up end points is very low due to yearly matching with official cause-of-death and hospital discharge registries. Very important research area in ULSAM is analysis of genetic factors affecting common diseases. We have DNA samples available from more than 1200 men. Using modern genotyping technologies, these samples have been analyzed for over 2.5 million SNPs. We are also planning to perform whole genome sequencing for all individuals with DNA samples available. Large number of researchers are using ULSAM data in their studies. ULSAM is involved in several international collaborations as well. Over 300 articles have been published from ULSAM initiation in 1970 and at least 30 doctoral theses explored data collected in our study. Purpose: The aim of Uppsala Study of Adult Men (ULSAM) is to investigate the risk factors for common diseases, including biochemical markers, variations in the genome and life style factors.乌普萨拉成年男性研究（Uppsala Study of Adult Men, ULSAM）最初是一项旨在识别心血管疾病代谢风险因素的健康调查，1970年所有居住在瑞典乌普萨拉的50岁男性均被纳入该研究。最终有82%的受试者（共2322名男性）参与了本次调查。此后，研究团队分别在这些男性年满60、70、77、82、88及93岁时对其进行了追踪随访。2015年春季完成的93岁随访中，原始队列男性的配偶也参与了此次调查。 ULSAM涵盖多个研究领域，收集了丰富的表型数据，具体包括糖与胰岛素代谢、血压、人体测量学指标、脂质与脂肪酸组成、膳食状况、认知功能、社会经济因素、遗传家族史、病史以及心血管疾病常见风险因素等。在最新一轮随访中，研究团队重点关注健康衰老的相关影响因素。本研究采用纵向研究设计，可在多个时间节点收集相同或相似的表型数据。由于研究团队每年与官方死因登记库及医院出院登记库进行数据匹配，失访率极低。 ULSAM的核心研究方向之一为分析影响常见疾病的遗传因素。目前研究团队已获取超过1200名男性的DNA样本，借助现代基因分型技术，已对超过250万个单核苷酸多态性（Single Nucleotide Polymorphism, SNP）位点进行了分析。研究团队还计划为所有持有DNA样本的受试者开展全基因组测序。当前已有大量研究者依托ULSAM数据集开展相关研究，同时ULSAM也参与了多项国际合作项目。自1970年项目启动以来，基于ULSAM数据已发表学术论文300余篇，另有至少30篇博士学位论文使用了本研究收集的数据集。 研究目标： 乌普萨拉成年男性研究（Uppsala Study of Adult Men, ULSAM）旨在探究常见疾病的风险因素，涵盖生物标志物、基因组变异及生活方式因素。