Next-generation sequencing analysis of circulating micro-RNA expression in response to parabolic flight as a spaceflight analogue

Understanding physiologic reactions to weightlessness is an indispensable requirement for safe human space missions. While adaptations of human organ systems in response to weightlessness have been described in former studies, their molecular background needs further elucidation. The study aims to analyse changes in the expression of circulating miRNAs in serum in response to gravitational changes induced by parabolic flight as a spaceflight analogue.

探究机体对失重环境的生理反应，是保障载人航天任务安全实施的必要前提。尽管以往研究已阐明人体器官系统对失重的适应性变化，但其背后的分子机制仍有待进一步阐释。本研究旨在以抛物线飞行作为航天模拟环境，分析人体血清中循环微RNA（circulating miRNAs）的表达水平随重力变化产生的改变。