Additional file 1 of The evolution of relapse of adult T cell acute lymphoblastic leukemia

Additional file 1. Additional tables. This file contains the supplementary tables referenced in the main text. Table S1 contains clinical information on the adult T-ALL cohort. Table S2 contains clinical information of the public pediatric cohorts. Table S3 contains the detected cancer genes by IntOGen. Table S4 contains the lists of ALL cancer genes of interest found in the literature separated in 3 subtables according to the type of alterations: SNVs and InDels (Table S4.a), CNV (Table S4.b), SV (Table S4.c). Table S5 contains the mutations (SNVs and InDels) that we consider as candidate drivers. Table S6 has the candidate driver CNVs (Table S6.a) and SVs (Table S6.b) of the cohorts analyzed. Table S7 has the time of divergence estimates between primary and relapse estimated as days pre-diagnosis of each patient.

补充文件1：补充附表。本文件包含正文引用的全部补充附表。表S1收录成人T细胞急性淋巴细胞白血病（T-cell Acute Lymphoblastic Leukemia, T-ALL）队列的临床信息。表S2收录公开儿科队列的临床信息。表S3收录IntOGen数据库检测得到的癌症基因。表S4收录文献中报道的全部感兴趣的急性淋巴细胞白血病（Acute Lymphoblastic Leukemia, ALL）相关癌症基因列表，根据变异类型分为3个子表：单核苷酸变异（Single Nucleotide Variants, SNVs）与插入缺失（Insertions and Deletions, InDels）（对应表S4.a）、拷贝数变异（Copy Number Variation, CNV）（对应表S4.b）、结构变异（Structural Variation, SV）（对应表S4.c）。表S5收录本研究判定为候选驱动突变的单核苷酸变异与插入缺失。表S6收录本次分析队列的候选驱动拷贝数变异（表S6.a）与结构变异（表S6.b）。表S7收录各患者原发灶与复发灶之间的分化时间估算值，以确诊前天数为计量单位。