Additional file 1 of Associations of screen-based sedentary activities with all cause dementia, Alzheimer’s disease, vascular dementia: a longitudinal study based on 462,524 participants from the UK Biobank

Additional file 1: Table S1. The single nucleotide polymorphisms (SNPs) that showed significant genome-wide association with AD, (the SNP loci of newly discovered genes in the UKB database were not included). Table S2. The time spent watching television (TV) instrumental Variables (IVs) were obtained from a GWAS of UKB participants (https://gwas.mrcieu.ac.uk/; GWAS ID: ukb-b-5192). Table S3. Extract the instrumental Variables (IVs) information that exposure (the time spent watching television ) to the outcome(Alzheimer's disease). Table S4. The exposure(the time spent watching television ) instrumental Variables (IVs) were matched to the effect allele of outcome(Alzheimer's disease) instrumental Variables (IVs). Table S5. Alzheimer's disease instrumental Variables (IVs) were obtained from a GWAS of Alzheimer Disease Genetics Consortium (ADGC), European Alzheimer's Disease Initiative (EADI)]. (https://gwas.mrcieu.ac.uk/; GWAS ID:ieu-b-2). Table S6. Extract the instrumental Variables (IVs) information that exposure (Alzheimer's disease) to the outcome(the time spent watching television). Table S7. The exposure(Alzheimer's disease) instrumental Variables (IVs) were matched to the effect allele of outcome(the time spent watching television ) instrumental Variables (IVs)

附加文件1：表S1 与阿尔茨海默病（Alzheimer's disease, AD）存在全基因组显著关联的单核苷酸多态性（single nucleotide polymorphisms, SNPs）（未纳入英国生物库（UKB）数据库中新发现基因的SNP位点）。
表S2 看电视时长的工具变量（instrumental variables, IVs）数据来自英国生物库参与者的全基因组关联研究（genome-wide association study, GWAS），来源链接：https://gwas.mrcieu.ac.uk/；全基因组关联研究编号：ukb-b-5192。
表S3 提取暴露因素（看电视时长）对结局（阿尔茨海默病）的工具变量信息。
表S4 将暴露因素（看电视时长）的工具变量与结局（阿尔茨海默病）工具变量的效应等位基因进行匹配。
表S5 阿尔茨海默病的工具变量数据来自阿尔茨海默病遗传学联盟（Alzheimer Disease Genetics Consortium, ADGC）、欧洲阿尔茨海默病倡议组织（European Alzheimer's Disease Initiative, EADI）的全基因组关联研究，来源链接：https://gwas.mrcieu.ac.uk/；全基因组关联研究编号：ieu-b-2。
表S6 提取暴露因素（阿尔茨海默病）对结局（看电视时长）的工具变量信息。
表S7 将暴露因素（阿尔茨海默病）的工具变量与结局（看电视时长）工具变量的效应等位基因进行匹配