Assessing spermatozoal small ribonucleic acids and their relationship to blastocyst development in idiopathic infertile males

Clinical testing strategies for diagnosing male factor infertility are limited. A deeper analysis of spermatozoa-derived factors could potentially diagnose some cases of unexplained infertility. Spermatozoa carry a rich and dynamic profile of small RNAs, which have demonstrated potential developmental importance and association with fertility status. We used next-generation sequencing to correlate sperm small RNA profiles of normozoospermic males (n=54) with differing blastocyst development rates, when using young donor oocytes.