IBS BAG

The IBS BAG includes teams from IBS (Grenoble) and external groups from CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study the structure-function relationships of proteins with a focus on human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2586 proposal and can be grouped under the following themes: host-pathogen interaction, new therapeutic targets, fundamental cellular mechanisms, membrane proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, cryo-EM, SAXS and NMR) together with other biophysical and biochemical studies and, more recently, the use of AI (AlphaFold) to fully understand the complexity of the biological macromolecular systems under study.

本数据集所属的IBS BAG汇聚了来自格勒诺布尔IBS研究所的研究团队，以及来自CEA-Cadarache（圣保罗勒兹迪朗斯）与IRBA（奥尔日河畔布雷蒂尼）的外部研究群组。本团队聚焦蛋白质的结构-功能关系研究，研究方向涵盖人类健康、生物技术与研究方法学三大领域。本数据集下的多数项目均为MX-2586研究提案的延续，可划分为以下六大研究主题：宿主-病原体互作、新型治疗靶点、基础细胞机制、膜蛋白、生物技术应用及研究方法学。部分项目采用整合研究策略，包括X射线晶体学（X-ray crystallography）、冷冻电镜（cryo-EM）、小角X射线散射（SAXS）与核磁共振波谱（NMR），结合其他生物物理与生物化学研究手段，并于近年引入人工智能（AI，AlphaFold）以全面解析所研究的生物大分子系统的复杂性。