Global evidence for programmed switching of gene expression from astrocytes to neurons in response to PTB depletion. Global evidence for programmed switching of gene expression from astrocytes to neurons in response to PTB depletion

RNA-seq data were generated on replicate samples of isolated astrocytes from mouse cortex or midbrain before and after conversion to neurons by depleting PTB for 2 or 4 weeks. Overall design: To characterize global switch in gene expression from astrocytes to neurons, we performed RNA-seq on isolated astrocytes from mouse cortex or midbrain and their converted neurons. As expected, typical astrocyte-specific genes were suppressed while neuronal-specific genes were induced upon shPTB induced neuronal conversion.