A facile one-pot, four-component synthesis of (Z)-isomer of rhodanine-oxindole derivatives under environmentally benevolent conditions

Herein, an efficient and sustainable one-pot, four-component access to rhodanine-oxindole derivatives is achieved by a reaction between primary amines, carbon disulfide, ethyl chloroacetate, and cyano-substituted alkenyl oxindoles. The reaction was conducted without any harsh conditions as well as exhausting workup in polyethylene glycol (PEG) as a green solvent at room temperature and delivered rhodanine-oxindole products in high yield. This publication is the first easy protocol to be reported for the rapid construction of new rhodanine-oxindole derivatives at room temperature without harsh conditions and via multicomponent reaction.

本文通过伯胺、二硫化碳、氯乙酸乙酯与氰基取代烯基氧化吲哚之间的反应，建立了一种高效且可持续的一锅法四组分合成若丹宁-氧化吲哚(rhodanine-oxindole)衍生物的方法。该反应无需苛刻反应条件与繁琐后处理，以聚乙二醇(PEG)作为绿色溶剂，在室温下即可进行，且能以高产率获得若丹宁-氧化吲哚产物。本工作首次报道了一种简便的合成工艺，可在室温、无需苛刻反应条件的前提下，通过多组分反应快速构建新型若丹宁-氧化吲哚衍生物。