Additional file 1 of Cardiac magnetic resonance markers of pre-clinical hypertrophic and dilated cardiomyopathy in genetic variant carriers

Additional file 1: Tables S1–S14. Table S1 Genes with pathogenic and likely pathogenic variants for hypertrophic cardiomyopathy or dilated cardiomyopathy. Table S2 Disease definitions based on ICD-10 codes and self-reported codes. Table S3 Baseline table for participants of the UK Biobank without established cardiac diseaseat the time of cardiac imaging visit. Table S4 Hazard ratio estimates for the association between CMR measurementsand the onset of atrial fibrillation and heart failure in people without established cardiac disease at the time of their imaging visit. Table S5 Hazard ratio estimates for the association between binary CMR measurementsand the onset of atrial fibrillation and heart failure in people without established cardiac disease at the time of their imaging visit. Table S6 Odds ratio estimates for the association between CMR measurementsand carriership of a HCM variant in people without established cardiac disease at the time of imaging visit. Table S7 Odds ratio estimates for the association between CMR measurementsand carriership of a DCM variant in people without established cardiac disease at the time of imaging visit. Table S8 Baseline characteristics before and after imputation. Table S9 Exploring potential non-linear associations between CMR measurements and carriership of cardiomyopathy-associated variants using a multivariable model. Table S10 Sex-specific subgroup analyses for the association between CMR measurements and carriership of cardiomyopathy variants. Table S11 Age-specific subgroup analyses for the association between CMR measurements and carriership of cardiomyopathy variants. Table S12 Heterogeneity of the observed associations between CMR measurements and the three most common HCM and DCM genes. Table S13 Odds ratio estimates for the association between CMR measurements and the three most common HCM and DCM-associated genes. Table S14 Common genetic variants in or around known cardiomyopathy genes associated with CMR measurements in GWAS.

附加文件1：表S1~S14。表S1：与肥厚型心肌病（Hypertrophic Cardiomyopathy, HCM）或扩张型心肌病（Dilated Cardiomyopathy, DCM）相关的致病性及疑似致病性变异基因。表S2：基于国际疾病分类第10版（ICD-10）编码与自我报告编码的疾病定义。表S3：英国生物库（UK Biobank）中，心血管磁共振成像（Cardiovascular Magnetic Resonance, CMR）检查时未确诊心脏疾病的参与者基线表。表S4：CMR检查时未确诊心脏疾病的人群中，心血管磁共振测量指标与心房颤动及心力衰竭发病关联的风险比（Hazard Ratio, HR）估计值。表S5：CMR检查时未确诊心脏疾病的人群中，二分类心血管磁共振测量指标与心房颤动及心力衰竭发病关联的风险比估计值。表S6：CMR检查时未确诊心脏疾病的人群中，心血管磁共振测量指标与肥厚型心肌病变异携带状态关联的比值比（Odds Ratio, OR）估计值。表S7：CMR检查时未确诊心脏疾病的人群中，心血管磁共振测量指标与扩张型心肌病变异携带状态关联的比值比估计值。表S8：插补前后的基线特征。表S9：采用多变量模型探索心血管磁共振测量指标与心肌病相关变异携带状态间潜在非线性关联。表S10：心血管磁共振测量指标与心肌病变异携带状态关联的性别特异性亚组分析。表S11：心血管磁共振测量指标与心肌病变异携带状态关联的年龄特异性亚组分析。表S12：心血管磁共振测量指标与三种最常见肥厚型心肌病及扩张型心肌病基因间观测关联的异质性。表S13：心血管磁共振测量指标与三种最常见肥厚型心肌病及扩张型心肌病相关基因关联的比值比估计值。表S14：全基因组关联研究（Genome-Wide Association Study, GWAS）中，与心血管磁共振测量指标相关的已知心肌病基因区域内或附近的常见遗传变异。