Variation analysis of SARS-CoV-2 complete sequences from Iran: Supplementary data

Aim: SARS-CoV-2 is an emerging coronavirus that was discovered in China and rapidly spread throughout
the world. The authors looked at nucleotide and amino acid variations in SARS-CoV-2 genomes, as well
as phylogenetic and evolutionary events in viral genomes, in Iran. Materials & methods: All SARS-CoV-
2 sequences that were publicly released between the start of the pandemic and 15 October 2021 were
included. Results: Themajority of mutations were found in vaccine target proteins, Spike and Nucleocapsid
proteins, and nonstructural proteins. The majority of the viruses that circulated in the early stages of the
pandemic belonged to the B.4 lineage. Conclusion: We discovered the prevalence of viral populations
in Iran. As a result, tracking the virus’s variation in Iran and comparing it with a variety of nearby
neighborhoods may reveal a pattern for future variant introductions.

研究目的：严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）是一种新发冠状病毒，于中国首次被发现并在全球快速蔓延。本研究针对伊朗境内SARS-CoV-2基因组的核苷酸与氨基酸变异情况，以及病毒基因组的系统发育与进化事件展开分析。
材料与方法：纳入新冠疫情暴发初期至2021年10月15日期间公开发布的所有SARS-CoV-2序列。
研究结果：多数突变位点分布于疫苗靶标蛋白刺突蛋白（Spike）、核衣壳蛋白（Nucleocapsid）以及非结构蛋白中。疫情早期在伊朗流行的病毒株多属于B.4进化分支。
结论：本研究明确了伊朗境内病毒种群的流行态势。据此，对伊朗境内的病毒变异情况开展追踪，并与周边多个地区进行比对，或可揭示未来新冠变异株的传入规律。