exon sequencing from twins with tuberculosis infection or not

Tuberculosis (TB) is a complex disease with a spectrum of outcomes for more than six decades; however, the genomic and epigenetic mechanisms underlying the highly heritable susceptibility to TB remain unclear. Integrated sequence-based genomic were conducted to identity the genetic factors associated with susceptibility to TB in two pairs of Mongolian monozygous twins. The single nucleotide polymorphisms (SNPs), insertions and deletions (InDels), copy number variant (CNV) were analyzed using next-generation sequencing.