Mg–Zn–RE合金膜在临界尺寸大鼠颅骨缺损中的降解行为、迁移机制及成骨活性

在本研究中，制备了一种含有6%锌和2.7%稀土元素（Y、Gd、La和Ce）的特定Mg–Zn–RE合金膜，以研究植入物的降解、迁移机制并引导体内骨再生。用扫描电子显微镜和透射电子显微镜对镁膜的微观结构和沉淀物进行了表征。在临界大小的大鼠颅骨缺损模型中，通过显微CT检查和硬组织切片，研究了植入2周、5周和8周后镁膜的降解过程及其对成骨的影响。然后，检测植入1周、2周和4周后器官中元素的分布，以探索其运输途径。

In this study, a specific Mg–Zn–RE alloy film containing 6% zinc and 2.7% rare earth elements (Y, Gd, La, and Ce) was fabricated to investigate the degradation and migration mechanisms of the implant and guide in vivo bone regeneration. The microstructure and precipitates of the magnesium alloy film were characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). In a critical-sized rat calvarial defect model, the degradation process of the magnesium alloy film and its effects on osteogenesis were investigated at 2, 5, and 8 weeks post-implantation via micro-computed tomography (micro-CT) examination and hard tissue sectioning. Subsequently, the elemental distribution in organs was detected at 1, 2, and 4 weeks post-implantation to explore the corresponding transport pathways.