RELATIONSHIP BETWEEN ESOPHAGITIS GRADES AND HELICOBACTER PYLORI

ABSTRACT Background: The Helicobacter pylori infection (HP) is related to the development of gastric lesions and lymphoma; however, it is not known if there is a relation with gastroesophageal reflux disease and reflux esophagitis. Aim: To evaluate HP's relationship with esophagitis in patients undergoing upper endoscopy. Methods: Observational, retrospective and cross-sectional study, being evaluated 9576 patients undergoing outpatient endoscopic examination during the period between January and December 2015. Were included patients with any esophageal alteration at the examination; greater than 18; of both genders; independent of the complaint or the reason for the examination, illness or drug use. Were excluded those with active bleeding during the examination and in use of anticoagulants. The variables gender, age, esophagitis and result of the urease test, were studied. For statistical analysis was used the Epi Info software 7.1.5.2. Results: Most of the samples consisted of women and the overall average age was 46.54±16.32 years. The presence of infection was balanced for gender: 1204 (12.56%) women and 952 (13.92%) men. Relating degree of esophagitis HP- and HP+ was observed that the type A was the most common (58.79%, n=1460); 604 (24.32%) had grade B; 334 (13.45%) grade C, and 85 (3.42%) grade D. In the relation between the grade of esophagitis with gender, esophagitis A was predominant in women and present in 929 (63.33%), followed by type B, 282 (46.68%), 136 C (40.71%) and D 30 (35.29%). In men 531 (36.36%) showed type A, 322 (53.31%) B, 198 (59.28%) C, and 55 (64.70%) D. Among the groups 40-50 and over 60 years there was a significant difference in whether have or not have HP+. Conclusion: There is no significant difference between HP infection and the different grades of esophagitis.

摘要

研究背景：幽门螺杆菌（Helicobacter pylori, HP）感染与胃黏膜病变及淋巴瘤的发生发展密切相关，但目前尚不明确其与胃食管反流病（gastroesophageal reflux disease）及反流性食管炎（reflux esophagitis）是否存在关联。

研究目的：探讨接受上消化道内镜检查（upper endoscopy）的患者中，幽门螺杆菌感染与食管炎的相关性。

研究方法：本研究为观察性回顾性横断面研究，纳入2015年1月至12月期间接受门诊内镜检查的9576例患者进行分析。纳入标准为：内镜检查发现存在任意食管病变、年龄≥18岁、男女不限，且不受就诊主诉、检查指征、基础疾病或用药情况限制。排除标准为：检查期间存在活动性出血者，以及正在使用抗凝药物者。本研究分析的变量包括性别、年龄、食管炎分级及尿素酶试验（urease test）结果，统计分析采用Epi Info 7.1.5.2软件完成。

研究结果：本研究队列以女性为主，总体平均年龄为46.54±16.32岁。幽门螺杆菌感染率在性别间分布均衡：女性感染者1204例，占比12.56%；男性感染者952例，占比13.92%。对比幽门螺杆菌阳性（HP+）与阴性（HP-）患者的食管炎分级情况，可见A级食管炎最为常见（58.79%，n=1460），其次为B级（24.32%，n=604）、C级（13.45%，n=334）及D级（3.42%，n=85）。按性别分析食管炎分级分布：女性以A级食管炎为主，共929例，占女性患者的63.33%；其次为B级（282例，46.68%）、C级（136例，40.71%）及D级（30例，35.29%）。男性患者中，A级食管炎531例（36.36%），B级322例（53.31%），C级198例（59.28%），D级55例（64.70%）。在40~50岁及60岁以上年龄组中，幽门螺杆菌感染与否存在显著差异。

研究结论：幽门螺杆菌感染与不同分级的食管炎之间无显著相关性。