RNA sequencing of sorted P17 murine endothelial cells from the OIR model with OSM or PBS intravitreal injection at P12. RNA sequencing of sorted P17 murine endothelial cells from the OIR model with OSM or PBS intravitreal injection at P12

IL-6 family cytokines as OSM modify angiogenesis to different degree. This study investigates the influence of intravitreal injection of OSM on the formation of neovascularization in the mice model of Oxygen-induced retinopathy (OIR). Mice at P12 were injected OSM or PBS , retinal cells isolated at P17 via sort and the transcriptome analyzed by RNA sequencing. Overall design: C57BL/6 mice were used for the established OIR model. Data consists of 5 OSM (Oncostatin M) and 6 PBS treated mice from three independent litters and OIR runs. M1-4, M5-8 and M9-11 are each from one litter and OIR run.