Recordings from ventral pallidum neurons in male rats undergoing fear discrimination

These data were collected from the ventral pallidum of 14 adult male Long Evans rats using 16 wire drivable microelectrode bundles. Data include 435 single units recorded from 194 behavior sessions. Fear discrimination sessions consisted of 16 trials with a mean inter-trial interval of 3.5 min. Auditory cues were 10 s in duration and consisted of repeating motifs of a broadband click, phaser, or trumpet. Each cue was associated with a unique probability of foot shock (0.5 mA, 0.5 s): danger, p = 1.00; uncertainty, p = 0.25; and safety, p = 0.00. Auditory identity was counterbalanced across rats. Foot shock was administered 2 s following the termination of the auditory cue on danger and uncertainty shock trials. The order of trial type presentation was randomly determined by the behavioral program, and differed for each rat, each session. The microelectrode bundle was advanced in ~84 μm steps every other day to record from new units during the following session. For three of the fourteen rats, the electrode bundle was centered at +0.36 mm from bregma, for six of the fourteen rats, the electrode bundle was centered at 0.00 mm from bregma, and the other five rats had electrodes centered at -0.36 mm from bregma. Data included are the result of spike sorting. Sample scripts used to visualize firing and behavior data from our main data file have been provided. These data have been published in Communications Biology and the complete methods are available with that publication.

本数据集采集自14只成年雄性Long Evans大鼠的腹侧苍白球（ventral pallidum），采用16通道可驱动微电极束（16-wire drivable microelectrode bundles）完成记录。数据集包含从194次行为实验会话中记录的435个单一神经元单位（single units）。恐惧辨别实验包含16组试次，平均试次间隔（inter-trial interval）为3.5分钟。听觉提示（auditory cues）时长为10秒，由宽带咔嗒声、相位声或小号声的重复片段组成。每个提示对应独特的足部电击（foot shock）参数（强度0.5 mA，持续0.5 s）：危险组（电击概率p=1.00）、不确定组（p=0.25）以及安全组（p=0.00）。听觉提示类型在大鼠间进行了平衡处理，以消除无关偏倚。在危险组与不确定组的电击试次中，足部电击于听觉提示结束后2秒施加。试次类型的呈现顺序由行为程序随机决定，且每只大鼠、每次实验会话的顺序均不相同。微电极束每隔一天以约84 μm的步距前进，以便在后续实验会话中记录新的神经元单位。14只大鼠中，3只的电极束以距前囟（bregma）+0.36 mm处为中心，6只以距前囟0.00 mm处为中心，其余5只的电极中心位于距前囟-0.36 mm处。本数据集包含经过尖峰分选（spike sorting）处理后的结果。我们已提供用于可视化主数据文件中神经元放电与行为数据的示例脚本。本数据集已发表于《Communications Biology》，完整实验方法可随该文献获取。