Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis

ABSTRACT Purpose It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods A systematic search of studies on the association between CALCR gene polymorphisms and calcium stone urolithiasis susceptibility was conducted in databases. Results Odds ratios and 95% confidence intervals were used to pool the effect size. Five articles were included in our meta-analysis. Conclusions CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insufficient data to fully confirm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis.

摘要
目的 已有研究表明，降钙素受体（calcitonin receptor, CALCR）基因多态性可能与钙性尿路结石症相关。由于现有研究结果混杂且尚无定论，本研究开展荟萃分析以总结并阐明二者间的关联。
材料与方法 本研究通过数据库系统检索关于CALCR基因多态性与钙性尿路结石症易感性的相关研究。
结果 采用比值比（Odds ratios, OR）及95%置信区间（95% confidence intervals, 95%CI）合并效应量。本次荟萃分析共纳入5篇文献。
结论 CALCR rs1801197多态性可能与钙性尿路结石症的患病风险升高相关。目前尚无足够数据可完全证实CALCR rs1042138多态性与钙性尿路结石症易感性之间的关联。未来需开展样本量更大、亚组设置更完善的设计严谨的研究，以验证本荟萃分析所发现的风险关联。