The remarkable pioneering contribution of Gaspar Vianna to the study of the neuropathology of Chagas disease

ABSTRACT Gaspar Vianna is considered one of the great names in Medicine and Science in Brazil. Yet, little prominence has been given to his studies in Neuropathology. He was the first to describe, in 1911, the histopathology and pathogenesis of chagasic encephalitis in the acute phase of Chagas disease, as well as the intracellular life cycle of Trypanosoma cruzi. Over 100 years have elapsed and Gaspar Vianna's pioneering study remains an example of a meticulous and still up-to-date description of central nervous system involvement in the acute phase of Chagas disease.

摘要：加斯帕尔·维亚纳（Gaspar Vianna）被公认为巴西医学与科学领域的杰出学者之一，但其在神经病理学领域的研究却长期未得到应有的重视。1911年，他首次描述了恰加斯病（Chagas disease）急性期恰加斯性脑炎的组织病理学与发病机制，以及克氏锥虫（Trypanosoma cruzi）的细胞内生命周期。时至今日，百余年光阴已逝，加斯帕尔·维亚纳的这项开创性研究依然是针对恰加斯病急性期中枢神经系统受累情况的细致严谨且仍具时效性的描述范例。